MULTI-DRUG RESISTANT BACTERIA AND ASSOCIATED FACTORS AMONG URINARY TRACT INFECTION SUSPECTEDREPRODUCTIVE AGED WOMEN IN JIMMA UNIVERSITY SPECIALIZED HOSPITAL, SOUTHWEST ETHIOPIA

Authors

  • Zeleke Gizachew
  • Tesfaye Kassa
  • Getnet Beyene
  • Rawleigh Howe
  • Biruk Yeshitela

Abstract

Background: Urinary tract infection (UTI) is commonly caused by bacteria and common in women. Eemergence of multi-drug resistant urinary tract infections are serious health issue with significant maternal morbidity and mortality.

Objective: The aim of this study was to assess the prevalence of multi-drug resistant bacteria and associated factors among urinary tract infection among suspected reproductive aged women.

Methods: Cross-sectional study was conducted from April to August 2016 on 424 study subjects in Jimma University Specialized Hospital. Data was collected by using pre-tested questionnaire and morning midstream urine samples were collected and processed according to standard operating procedures. Antimicrobial susceptibility testing was done following Clinical Laboratory Standards Institute 2014. Cell surface hydrophobicity, biofilm production, extended spectrum beta-lactamases & carbapenemases productions were tested.

Results: The prevalence of UTI among suspected reproductive aged women was 22.9%. E. coli was the most frequent isolates with a rate of 57% among isolated bacteria followed by Klebsiella species (24.7%). Over 90% of the isolates were multi-drug resistant. Resistance pattern for ampicillin was 100% followed by ticarcillin (92.4%) and colistin (86%) but less resistance rate for imipenem (13%). Multivariate analysis revealed that risck factos such as previous history of hospitalization, extended spectrum beta-lactamases production and strong biofilm production were significaltly associated with multidrug resistance at p-value <0.05

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2019-04-12

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