Antibody levels against HBV after vaccination and sero-prevalence of HBV in children in Addis Ababa, Ethiopia

Authors

  • Seifegebriel e Teshom
  • Habtamu Biazin
  • Tamrat Abebe
  • Adane Mihret
  • Abraham Aseffa
  • Rawleigh Howe

Abstract

Background:Around two billion people have been infected with HBV worldwide, and more than 240 million are chronic carriers. Vaccine introduction for HBV in children was officially launched by WHO in 1980. Since then the vaccine response level has been determined in different countries. However, there is limited study conducted in Ethiopia to assess the response level and effectiveness of HBV vaccine against the virus since the introduction of the vaccine in 2007.

Objectives: The aim of the study was to determine antibody levels against HBV after hepatitis B vaccination and assess sero-prevalence of HBV in children in Addis Ababa, Ethiopia.

Methods: A cross sectional study was conducted using a multistage probability sampling technique. Four hundred and fifty children between the ages of 5 and 8 years living in one of three sub cities of Addis Ababa were enrolled. Three to four ml of blood was collected from each participant and socio demographic and associated factors were obtained through a structured questionnaire.  ELISA was done to determine antibody levels against HBV.

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Published

2019-04-17

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