• Dr Megha Sreekant Hurakadli Hawassa University
  • Dr Somanath Mungarwadi Hawassa University
  • Dr Manjunath K.S Sri Hasanamba Dental college
  • Dr Manoj Kumar Jain sri hasanamba dental college


Background: Surgical removal of third molar is most common surgical procedures carried out in oral and maxillofacial surgery and is quite stressful for many patients. Surgical removal of third molar results in an intense inflammatory response that consists of edema, erythema, pain, warmth and loss of function

Objective: objective is to evaluate the efficacy of submucosally infiltrated dexamethasone in reducing inflammatory sequelae following surgical removal of lower third molar and its comparison with that of control group.

Methods: This study was conducted on 80 patients having mesio-angularly impaced mandibular third molars as an outpatient procedure in the Department of Oral Maxillofacial Surgery, they were randomly divided into two groups, each group of 40 patients. One group of patients were administered 8mg dexamethasone submucosally 5 mins prior to the surgery after achieving local anesthesia which was called as group A. Other group of patients received normal saline submucosally 5mins prior to the surgery called as group B. Swelling, pain and trismus were measured on the first, third and the seventh post-operative days.

 Results: results of this study revealed that inj dexamethasone administered submucosally was effective in controlling post-operative swelling and mouth opening.

 Conclusion: Submucosal route of dexamethasone is quite simple, cost effective, less invasive, painless, convenient to surgeon and the patient in minimizing the post-operative sequellae and discomfort associated with the surgical removal of impacted lower third molars.

Key Words: Dexamethasone, Submucosal, Pain, Swelling, Trismus and Third molar

Author Biographies

Dr Megha Sreekant Hurakadli, Hawassa University
Assistant Professor in the Dept Of Oral and Maxillofacial Surgery
Dr Somanath Mungarwadi, Hawassa University
Assistant Professor in Dept of Oral and Maxillofacial Surgery
Dr Manjunath K.S, Sri Hasanamba Dental college
Head of the department of Oral and Maxillofacial Surgery
Dr Manoj Kumar Jain, sri hasanamba dental college
Reader in dept of Oral and Maxillofacial Surgery


Khateeb T.L, Marouf H, Mahammod M.A. Clinical Evaluation of Dexamethasone Vs Methylprednisolone for reducing postoperative inflammatory sequelae following third molar surgery. The Saudi Dental Journal, 1996;8(3):131-5.

Olga Garcı´a-Martı´nez, Lourdes Dı´az-Rodrı´guez, Laura Rodriguez- Perez, Elvira De Luna-Bertos, candela Reyes Botella, C.concepcion Ruiz .Effect of acetaminophen, ibuprofen and methylprednisolone on different parameters of human osteoblast-like cells. Archieves of Oral Biology 2011;56:317-23.

Grossi GB et al. Effect of sub mucosal injection of Dexamethasone on postoperative discomfort after third molar surgery: A Prospective study. J Oral Maxillofac Surg, 2007;65(11): 2218-26.

Kim K, Brar P, Jakubowski J, Kaltman S, Lopez E. The use of corticosteroids and nonsteroidal anti-inflammatory medication for the management of pain and inflammation after third molar surgery: A review of the literature. Oral Surg Oral Med Oral Pathol Oral RadiolEndod 2009;107:630-40.

Laureano Filho JR, Maurette PE, Allais M, Cotinho M, Fernandes C. Clinical comparative study of the effectiveness of two dosages of Dexamethasone to control postoperative swelling, trismus and pain after the surgical extraction of mandibular impacted third molars. Med Oral Patol Oral Cir Bucal. 2008;13(2):129-32.

Mardirossian G, Cooper SA. Comparison of the analgesic efficacy of Flurbiprofen and Aspirifectn for postsurgical dental pain. J Oral Maxillofac Surg 1985;43:106-109.

Yuasa H, Sugiura M. Clinical post-operative findings after removal of impacted mandibular third molars: Prediction of postoperative facial swelling and pain based on preoperative variables. Br J Oral Maxillofac Surgery 2004;42:209-14.

Omer Waleed Majid, Waseem Khalid Mahmood. Effect of submucosal and intramuscular dexamethasone on sequelae after third molar surgery: comparative study: British Journal of Oral and Maxillofacial Surgery (2010)

Osunde OD, Adebola RA And Omeje UK. Management of inflammatory complications in third molar surgery: A review of the literature. African Health Sciences 2011; 11(3): 530 – 537

Alexander RE, Throndson RR. A review of perioperative corticosteroid use in dentoalveolar surgery. Oral Surg Oral Med Oral Pathol Oral RadiolEndod. 2000;90:406-15.

Leone M et al. Comparison of methyl prednisolone and ketoprofen after multiple third molar extraction: a randomized controlled Study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103(1):e7-9.

Lin S, Levin L, Emodi O, Abu El-Naaj I, Peled M. Etodolac versus dexamethasone effect in reduction of postoperative symptoms following surgical endodontic treatment: A double-blind study. Oral Surg Oral Med Oral Pathol Oral RadiolEndod 2006;101:814–817.

Geoffery L Howe. Minor oral surgery. Third edition: page no 41.

Warraich R et al. Evaluation of postoperative discomfort following third molar surgery using submucosal dexamethasone e a randomized observer blind prospective study. Oral Surg Oral Med Oral Pathol Oral Radiol 2013;116:16-22.

Original Article