Seroprevalence of Hepatitis B and Hepatitis C Virus and their Associated Factors among Mothers Living in Harar Town, Eastern Ethiopia
Infection by Hepatitis B virus (HBV) and Hepatitis C Virus (HCV) among mothers have high rate of vertical transmission and horizontal transmission and also have adverse effect on both the mother and the child. Understanding the epidemiology of these viruses could be valuable to take appropriate preventive measures.
To determine the seroprevalence and associated factors of HBV and HCV infection among mothers living in Harar town, Ethiopia.
Materials and Methods
A cross sectional study was conducted among 461 mothers living in Harar, Eastern Ethiopia from March 1 – May 30, 2017. Systematic random sampling method was used to select the study participants. Data was collected by face to face interview using pre tested structured questioners. Five millilitre of venous blood was collected with plain tubefrom each study subject and serum was tested for hepatitis using a sandwich third generation Enzyme Linked Immunosorbent Assay (ELISA) for HBsAg and anti HCV by using Bio-Rad ELISA kits. Data was analysed by using Statistical Package for Social Sciences (SPSS) version 16.0.
WHO (2010). World Health Organization A63/15 Viral Hepatitis Re¬port by Secretariat. 2010. Available from: http://apps.who.int/gb/ebwha/pdf_files/ WHA63/A63_15-en.pdf Accessed 24 Septem¬ber 2013.
Seid, M., Gelaw, B., Assefa, A.(2014) Sero-prevalence of HBV and HCV Infections among Pregnant Women Attending Antenatal Care Clinic at Dessie Referral Hospital, Ethiopia. Advances in life science and health. 1(2):109-120.
Loh, K.Y. and Kew, S.T. (2006) Hepatitis b infection: what the primary care doctors should know. Malaysian Family Physician, 1(1): 3
Chen, S.L. and Morgan, T.R. (2006)The natural history of hepatitis C virus (HCV) infection. International Journal of Medical Sciences, 3(2), 47-.54
James M, Robert N, Marija B, Ada K, Elizabeth M, Lucy M, Fabiola M, and Nora M, (2014) Prevalence of hepatitis C virus in mothers and their children in Malawi; Tropical Medicine and International Health;20 (5) :638–642
Yohanes T., Zerdo, Z., and Chufamo. (2015)Seroprevalence and Predictors of Hepatitis B Virus Infection among Pregnant Women Attending Routine Antenatal Care in Arba Minch Hospital, South Ethiopia: Hepatitis Research and Treatment.92:1-7.
WHO. (2009).World Health Organization. Hepatitis B vaccines Weakly Epidemiology Rec., 84: 405±419.
Molla S, Munshea A and Nibret E. (2014). Seroprevalence of hepatitis B surface antigen and anti HCV antibody and its associated risk factors among pregnant women attending maternity ward of Felege Hiwot Referral Hospital, northwest Ethiopia: a cross-sectional study. Virology Journal .12(204):1-9
Harari Regional Health Bureau. (2015)Health survey of Harari region. Harar, Ethiopia.
Bio-Rad, bd Raymond Poincaré Marnes-la-Coquette.(2017) – France Tél.: +33 1 47 95 60 00 01/2009 Fax.: +33 1 47 41 91 33 Code: 883569
Mohd Hanafiah K, Groeger J, Flaxman AD, Wiersma ST. (2013) Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Hepatology. , 57 (4):1333–1342.
Kabinda, J.M., Akilimali, T.S., Miyanga, A.S., Donnen, P. and Michèle, D.-W. (2015) Hepatitis B, Hepatitis C and HIV in Pregnant Women in the Community in the Democratic Republic of Congo. World Journal of AIDS, 5, 124-130.
Awole,M and Gebre-Selassie,S.(2005) Seroprevalence of HBsAg and its risk factors among pregnant women in Jimma, Southwest Ethiopia, Ethiopian Journal of Health Development, 19, (1): 45–50.
Tegegne D, DestaK, Tegbaru Band and Tilahun T. (2014) Seroprevalence and transmission of Hepatitis B virus among delivering women and their new born in selected health facilities, Addis Ababa, Ethiopia: a cross sectional study BMC Research Notes7:239-244
Ngaira J,&, Kimotho J, Mirigi I, Osman S, Zipporah N,Lwembe R, and Ochwoto M.(2014) Prevalence, awareness and risk factors associated with Hepatitis B infection among pregnant women attending the antenatal clinic at Mbagathi District Hospital in Nairobi, Kenya .Pan African Medical Journal. 24:315
Oladimeji, A. Pius,A , AdekunleA.E, Temi,A.P.,Abiodun,O.,Olusola.A., Peter, & Babatunde,O. (2013) Seroprevalence of hepatitis B infection in pregnant women at the Ekiti State University Teaching Hospital, Ado-Ekiti, Southwest Nigeria. African Journal of Internal Medicine, 1 (4): 023-025.
Bani I, Mahfouz M, Maki E, Gaffar A, Elhassan I, Yassin A, Ageely H. (2012) Prevalence and Risk Factors of Hepatitis B Virus among Pregnant Women in Jazan Region- Kingdom of Saudi Arabia.Journal of Biology, Agriculture and Healthcare 2(7):39-43
Shoghli, A., Nabavi,S., Alavian,S., Kolifarhood, G., Goya,M. Namazi R, Fallahnezhad M, Mohajeri M, Mousavinasab N, Zanjani R, Saeini M, and Jalilvand M(2014) Hepatitis B surface antigen prevalence in pregnant women: A cross-sectional survey in Iran. Int J Prev Med; 5(3): 213–218.
Xeuatvongsa A, Komada K, Kitamura T, Vongphrachanh P, Pathammavong C, Kongxay Phounphenghak K, Thongchanh Sisouk T, Darouny Phonekeo D, Sengkeopaseuth B, Som-Oulay V, Ishii K, Wakita T, Sugiyama M, Hachiya M (2014) Chronic Hepatitis B Prevalence among Children and Mothers: Results from a Nationwide, Population-Based Survey in Lao People’s Democratic Republic. PLoS ONE 9(2):28-36.
Abebe A., Nokes, D.J., Dejene, A., Enquselassie, F. Messele, T and Cutts, F.T. (2003) Seroepidemiology of hepatitis B virus in Addis Ababa, Ethiopia: transmission patterns and vaccine control, Epidemiology and Infection, 131(1): 757–770.
Semaw, A., Awet, H, and Yohannes, M.(2015)Sero-prevalence of hepatitis B surface antigen and associated factors among pregnant mothers attending antenatal care service, Mekelle, Ethiopia: evidence from institutional based quantitative cross-sectional study, World Academy of Science, Engineering and Technology: Medical and Health Sciences, 2(9):663-668
Umare A, Seyoum B, Gobena T, Haile Mariyam T (2016) Hepatitis B Virus Infections and Associated Factors among Pregnant Women Attending Antenatal Care Clinic at Deder Hospital, Eastern Ethiopia. PLoS ONE 11(11):1-11
Zhang.,Yu.,Weiming F, Lichun F., Xiaohui Gao, Yan Guo, Wenming Huang and Yukai Du (2014).Hepatitis B surface antigen prevalence among 12 393 rural women of childbearing age in Hainan Province, China: a cross-sectional study. Virology Journal .10(25):422-426
Javed N and Naz S. (2013) Prevalence of Hepatitis B infection in married women of child bearing age in district Islamabad. Gomal Med J Sci, 11: 216-219.
Zenebe, Y. &, Mulu, W. Yimer, M., Abera, B. (2015) Sero-prevalence and risk factors of hepatitis C virus infection among pregnant women in Bahir Dar city, Northwest Ethiopia: cross sectional study Pan African Medical Journal. 21 :( 158)
Ugbebor O, Aigbirior M, Osazuwa F, Enabudoso E and Zabayo O.(2010) The prevalence of hepatitis B and C viral infections among pregnant women.N Am J Med Sci, 3(5): 238–241.
Esan J , OmisakinC,Ojo-Bola T, Owoseni M, Fasakin K, Ogunleye A( 2014) "Sero-Prevalence of Hepatitis B and Hepatitis C Virue Co-Infection among Pregnant Women in Nigeria." American Journal of Biomedical Research 2(1): 11-15
Osman AMM, Mirghani OA , Gasim GI, Adam I. (2014)Hepatitis B Virus, Hepatitis C Virus and Human Immunodeficiency Virus Infections among Pregnant Women in Central Sudan. Original Article 9 (2): 91-96
Fisseha G. (2015) “Young women sexual behaviour and self-reported sexually transmitted diseases in northern Ethiopia a cross sectional study,” European Journal of Preventive Medicine, 3(3):55–62
Ishaq, T., Mohammad Ishaq Khattak, Said Amin, Najib ul Haq. (2011) Frequency and Risk Factors for Hepatitis C Among Pregnant Women Gomal Journal of Medical Sciences, 9(2):74-83