Magnitude and Predictors of Adequate Immunologic Response in Saint Paul’s Hospital Millennium Medical College ART Clinic, Addis Ababa, Ethiopia: a Retrospective Cohort
Background: Effectiveness of antiretroviral therapy (ART) can be measured with a change in CD4 cells counts. The aim of this study is to estimate the magnitude and identify predictors of adequate immunologic response (AIR) in Saint Paul’s Hospital Millennium Medical College (SPHMMC).
Methods: A retrospective cohort study was conducted among individuals, who are enrolled in SPHMMC ART clinic in the period September, 2011- September, 2016. The data was collected using a data abstraction tool adopted from the patient’s chart. And managed and analyzed by using SPSS, Version 20.0. Descriptive statistics was used to describe study participants characteristics. In addition, a multiple binary logistic regression was used to identify predictors of AIR.
Result: A total 662 individuals participated in this study and 445(67.2%) of them had AIR. Disclosing HIV status; increase in base line hemoglobin; being stage II; and working functional status were more likely to have AIR (Adjusted Odds Ratio (AOR) =1.79 [95% Confidence Interval(CI): 1.16, 2.76]), (AOR =1.14 [95% CI: 1.05, 1.24]), (AOR =2.66 [95% CI: 1.29, 5.45]), and (AOR =1.84 [95% CI: 1.03, 3.29]) respectively. And attending primary education; and increase in baseline CD4 were less likely to have AIR (AOR =.55 [95% CI: .31, .96]) and (AOR =.90 [95% CI: .84, .96]) respectively.
Conclusion: The government and other concerned bodies should work in encouraging people living with HIV (PLHIV) to disclose their status and educating the community should be given attention.