Treatment outcome of tuberculosis patients at Ekiti State University Teaching Hospital, Nigeria
Keywords:Tuberculosis, HIV/AIDS, Outcome, Treatment, TB/HIV
Background: Tuberculosis (TB) is a major public health challenge in developing countries. Clinical audit of treatment outcome is a major indicator of the performance of the TB control programme.
Objectives: The aim of this study was to evaluate tuberculosis treatment outcomes and associated factors among patients attending the directly observed tuberculosis short-course (DOTS) facility in a tertiary healthcare center in Nigeria.
Methods: An eight-year retrospective study of registered TB patients from October 2008 to November 2016. The treatment outcome of patients was categorized using the National TB Control programme guideline.
Results: A total of 592 complete patients’ records was reviewed. There was a slight male preponderance (322, 54.4%) and the majority of the patients were newly diagnosed of tuberculosis (537, 90.7%) especially pulmonary tuberculosis (520, 87.8%). The mean age of registered patients was 38 ± 0.6 years. More than half of the patients (339, 57.2%) had smear-positive pulmonary TB (PTB), (181, 30.6%) smear-negative PTB, while (72, 12.2%) had extra-pulmonary TB (EPTB). Four hundred and three patients (91.6%) had successful treatment outcomes (cured and treatment completed), and the predictors of TB treatment outcome were EPTB (OR 11.4 CI 2.30-57.5 p-value=0.003) and TB/HIV co-infection (OR 0.08 CI 0.025-0.24 p<0.05). TB/HIV co-infection accounted for 13% of patients and this was found to be associated with female gender (OR 2.5 CI 1.48-4.22, p-value≤0.0001) and EPTB (OR 0.2 CI 0.27-12.90, p-value=0.032).
Conclusion: Satisfactory treatment outcome when compared to the global target. However, proper integration of TB/HIV programme would further improve the outcome.
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