Factors associated with congenital anomalies among young infants at Tikur Anbessa Hospital, Addis Ababa, Ethiopia

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  • Submited: September 21, 2020
  • Published: September 23, 2020

Abstract

Introduction: Congenital anomalies require multitude of surgical procedures at a very early life and impose a large impact on the lives of patients and parents and yet causes are still largely unknown, but assumed to be multifactorial. A few studies focused on environmental risk factors, but evidence is still scarce.

Methods: This is a case control study of infants less than 3 months of age   with congenital anomalies evaluated or admitted to the hospital between December 1 2017 and May 31 2018. Face-to-face interviews with parents of young infants were carried out to collect socio-demographic and clinical information.

Results: Analysis of the data showed that among 200 young infants with congenital anomalies enrolled in the study, gastrointestinal system is most commonly affected organ system. Maternal factors that were significantly associated with congenital anomalies included the lack of peri-conceptional use of folic acid (OR = 3.6; 95% CI = 1.6-7.7; p = 0.005), an inadequate attendance to antenatal clinic (OR = 2.3; 95% CI = 1.5-3.6; p < 0.001), family history of congenital anomalies in 3 %of cases (OR 2.4:95% CI =1.5-3.6; P< 0.001). Infant factors that were significantly associated with congenital anomalies were male sex, and birth weight of 2.5 kg or less.

Conclusions: In this study, the proportion of women taking folic acid supplements during pregnancy was very low and mothers of infants with congenital anomalies has less antenatal follow up.

 

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References

  1. Singh A, Gupta RK: Pattern of congenital anomalies in newborn: a hospital based prospective study. JK Sci 2009, 1:34–36.
  2. Parmar A, Rathod SP, Patel SV, Patel SM: A study of congenital anomalies in newborn. NIJRM 2010, 1:13–7.
  3. Malla BK: One year review study of congenital anatomical malformation at birth in Maternity Hospital (Prasutigriha), Thapathali, Kathmandu. Kathmandu Univ Med J 2007, 5(4):557–560.
  4. Swain S, Agrawal A, Bhatia BD: Congenital malformations at birth. Indian Pediatr 1994, 31(10):1187–1191.22.
  5. Alverson CJ, Strickland MJ, Gilboa SM, Correa A: Maternal smoking andcongenital heart defects in the Baltimore-Washington Infant Study.Official J Am Acad Pediatr 2011, 127(3):647–653.
  6. Hazem SEM, Hassan SK, Alaa Eldeen MI, Rami M: Epidemiology of birth defects in Women’s health university center Assiut–Egypt: an observational cross-sectional study. Am J Sci 2012, 8:777–781.
  7. Hackshaw A, Rodeck C, Boniface S: Maternal smoking in pregnancy and birth defects. Hum Reprod Update 2011, 17(5):589–604.
  8. Mehrabi Kushki BZ A: The effect of consanguineous marriages oncongenital malformation. J Res Med Sci 2005, 10(5):298–301.
  9. El Koumi MA, Al Banna EA, Lebda I: Pattern of congenital anomalies innewborn: a hospital-based study. Pediatr Rep 2013, 5(1):0-3.doi:10.1186/1756-0500-7-195
  10. Adeleye AO, Olowookere KG: Central nervous system congenital anomalies: a prospective neurosurgical observational study from Nigeria.Congenit Anom (Kyoto) 2009, 49(4):258–261.
  11. Wisniewska K, Wysocki J: The importance of folic acid in the primary prevention of congenital malformations. Arch Perinat Med 2008, 14(2):32–40.
  12. Godwin KA, Sibbald B, Bedard T, Kuzeljevic B, Lowry RB, Arbour L: Changes in frequencies of select congenital anomalies since the onset of folic acid fortification in a Canadian birth defect registry. Canad J Public Health 2008, 99(4):271–275.
  13. Salerno P: Folic acid in congenital malformations prevention. Ann Ig 2009,22(4):10–12.
  14. Verity C, Firth H, Constant C: Congenital abnormalities of the central nervous system. Neurol Neurosurg Psychiatry 2003, 74:i3–i8.
  15. Penchaszadeh VB: Preventing congenital anomalies in developing countries. Community Genet 2002, 5:61–69.
  16. Granado S: Congenital malformations in Rio de Janeiro, Brazil: prevalence and associated factors. Cad Saude Publica 2006, 22(11):2423–2431.
  17. Swain S, Agrawal A, Bhatia BD: Congenital malformations at birth.Indian Pediatr 1994, 31(10):1187–1191.
  18. Mosayebi Z, Movahedian AH: Pattern of congenital malformations inconsanguineous versus nonconsanguineous marriages in Kashan, IslamicRepublic of Iran. East Mediterr Health J 2007, 13(4):868–875.
  19. Delport SD, Christianson AL, van den Berg HJ, Wolmarans L, Gericke GS:Congenital anomalies in black South African liveborn neonates at anurban academic hospital. S Afr Med J 1995, 85(1):11–15.World Health Statistics 2008. Geneva: World Health Organization; 2008.
  20. 5. Parmar A, Rathod SP, Patel SV, Patel SM: A study of congenital anomalies in newborn. NIJRM 2010, 1:13–7.
  21. Emanuel I, Huang SW, Gutman LT, Yu FC, Lin CC: The incidence of congenital malformations in a Chinese population: the Taipei collaborative study. Teratology 1972, 5:159–169.
  22. Malla BK: One year review study of congenital anatomical malformation at birth in Maternity Hospital (Prasutigriha), Thapathali, Kathmandu.Kathmandu Univ Med J 2007, 5(4):557–560.
  23. Muga R, Mumah S, Juma P: Congenital malformations among newborns in Kenya. Afr J Food Nutr Sci 2009, 9(3):814–829.
  24. Ndibazza J, Lule S, Nampijja M, Mpairwe H, Oduru G, Kiggundu M, Akello M,Muhangi L, Elliott AM: Brief report a description of congenital anomalies among infants in Entebbe, Uganda. Clin Mol Teratol 2011, 91:857–861.
  25. Shawky RM, Sadik DI: Congenital malformations prevalent among Egyptian children and associated risk factors. Egypt J Med Human Genet 2011, 12(1):69–78.
  26. Manyama M, Rolian C, Gilyoma J, Magori CC, Mjema K, Mazyala E, Kimwaga E, Hallgrimsson: An assessment of orofacial clefts in Tanzania. BMC Oral Health 2011, 11:5.
  27. Reece EA. Diabetes-induced birth defects: what do we know? What can we do? Curr Diab Rep 2012; 12:24–32.
  28. Honein, M.A., Rasmussen, S.A., Reefhuis, J.,Romitti, P., Lammer, E.J. & Sun, L. et al. (2007).Maternal smoking, environmental tobacco smoke, and the risk of oral clefts. Epidemiology.18(2), 226–33.
How to Cite
Getachew, H. ., & Derbew, M. . (2020). Factors associated with congenital anomalies among young infants at Tikur Anbessa Hospital, Addis Ababa, Ethiopia. Ethiopian Medical Journal, 58. Retrieved from https://emjema.org/index.php/EMJ/article/view/1701

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