PATTERN OF ANTIHYPERTENSIVE THERAPY AMONG DIABETIC-HYPERTENSIVE PATIENTS IN ZEWDITU MEMORIAL HOSPITAL, ADDIS ABABA
Introduction: Diabetes mellitus is becoming a common chronic disease in both developed and developing nations and is associated with a significant cardiovascular disease morbidity and mortality. The presence of hypertension in patients with diabetes mellitus will double the risk of cardiovascular disease including coronary heart disease, congestive heart failure, ischemic and hemorrhagic stroke, renal failure and peripheral arterial disease.
Objective: The aim of this study was to assess the pattern of antihypertensive drug therapy among diabetic-hypertensive patients in Zewditu Memorial Hospital Diabetic Clinic in Addis Ababa.
Methods: This is a hospital based retrospective review of medical records of 382 diabetic-hypertensive patients who visited Zewditu Memorial Hospital Diabetic Clinic in the period between August 2014 and January 2015.
Results: The most frequently prescribed antihypertensive drug classes were ACEI in 321 (84%) followed by CCB in 229(60%) and BB in 145 (38%) patients. Enalapril, nifedipine, atenolol, losartan and hydrochlorthiazide was the only ACEI, CCB, BB, ARB and DI prescribed respectively. Enalapril was used as a monotherapy in 73(19%) and nifedipine in 26(7%) patients. The recommended target SBP <140 mmHg and DBP <90mmHg was achieved in only 57(15%) patients while the rest 325(85%) did not attain the target blood pressure. Renal function was assessed in 351(92%) patients, of whom 23(6%) had renal impairment with an estimated GFR < 60 ml/min.
Conclusion: The pattern of antihypertensive drug therapy in our patients was consistent with the current treatment guidelines. However, majority of diabetic-hypertensive patients did not reach target blood pressure.
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