ASSOCIATION OF CHRONIC HEPATITIS C WITH DIABETES MELLITUS AMONG ETHIOPIAN PATIENTS: A CASE-CONTROL STUDY
Background. Chronic hepatitis C virus (HCV) is a pandemic affecting more than 170 million people worldwide. It leads to cirrhosis, hepatocellular carcinoma, and extra hepatic complications like type 2 Diabetes Mellitus (DM) in up to 13-33%.
Objective. To assess the association of chronic HCV with DM among adult Ethiopians.
Patients and Methods.This case control study was conducted at Adera Medical and Gastroenterology center in Addis Ababa during September 1 through November 30,2015. One hundred forty one cases and 359 controls were included in the study after consent. Data regarding DM risk factors,CBC, liver chemistry, FBS, andsonographywere collected. HCV screening was done by rapid antibody test and confirmed by ELISA followed by PCR genotype and viral load testing fortreatment. The data were analyzed using SPSS version 20 software including Odds ratio and 95% confidence interval.
Results. Among the 141 cases with HCV infection, most (69.5 %) were from Addis Ababa, 54% were females with mean age of 50 years.. Genotypes 4 and 1 were predominant in 70% and 20%, respectively. Type 2 DM was diagnosed among 31% and 27% of the males and females with HCV infection, respectively in contrast to 4.2 % and 2.8% among matching controls.
Conclusion. HCV infection is significantlyassociated with development of type 2 Diabetes Mellitus, as opposed to controls, indicating the importance of screening for DM and vice versa.
Key words: HCV, Diabetes Mellitus, Ethiopia
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