LATENT TUBERCULOSIS AMONG ADULT ETHIOPIAN PATIENTS AT CHEST CLINIC, TIKURANBESSA SPECIALIZED HOSPITAL, ADDIS ABABA, ETHIOPIA

Authors

  • Amsalu Bekele Addis Ababa University college of health Sciences
  • Senait Ashenafi Departement of Pathology, Addis Ababa University and Karolinska Institute, Sweden
  • Getachew Aderay Department of Internal Medicine, School of Medicine, Addis Ababa University, Ethiopia
  • Getachew Assefa Department of Radiology, Addis Ababa University, Ethiopia
  • Abraham Aseffa Armauer Hansen Research Institute (AHRI), Ethiopia
  • Jan Anderssen Karolinska Institute, Sweden
  • Susanna Brighenti Karolinska Institute, Sweden

Abstract

Background: One-third of the world population is infected with mycobacterium tuberculosis. Most people exposed to mycobacterium tuberculosis showed no evidence of active disease. About 5-10% of latent tuberculosis infection without HIV will progress to developed active tuberculosis in their lifetimes. This study was conducted to determine the magnitude of Latent TB among the adult population at a teaching and referral Hospital in Ethiopia.

Methods: This study was conducted at the Chest clinic of Tikur Anbessa Specialized Hospital during 2010-2013.The study was a cross-sectional study conducted among healthy adults after informed consent was obtained from each individual. Tuberculin skin test and Interferon Gamma whole blood assay (Quantiferon-Tuberculosis-Gold) was performed using Enzyme linked Immuno-sorbent Assay. Average CD4, CD8, CD3 and CD4:CD8 ratio was determined for all study participants. 

Results:From a total of 70 healthy adults tested for latent tuberculosis infection using Quantiferon Gold,45(64%) tested positiveand 25 (36%) were negative for latent tuberculosis infection. From the sixty six healthy individuals who were tested using tuberculin skin test for latent tuberculosis infection, 42 (62%) individuals were Tuberculin skin test positive and 25 (38%) individuals were Tuberculin skin test negative.  Average CD4, CD8, CD3 and CD4:CD8 ratio was 748, 598, 1401 and 1.4, respectively.

Conclusions: The magnitude of latent tuberculosis infection was high in this study, which reflects existing high prevalence of tuberculosis.Tuberculin skin test and Quantiferon-Tuberculosis-Goldassay show similar efficacy for the diagnosis of latent tuberculosis infection in healthy Ethiopian adults.  The absolute CD4 T-cell counts of healthy HIV-negative Ethiopian's are considerably lower than other countries.

Key Words: Latent tuberculosis ,Chest clinic , adult population , TAH

 

Author Biography

Amsalu Bekele, Addis Ababa University college of health Sciences

Assistant professor of Medicine,Department of Internal Medicine,college of health sciences,AAU

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2016-09-23

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