A Unique Case Report of Tracheobronchomalacia in an HIV Patient

  • Ermias Merkebu Amare Addis Ababa University, College of Health Sciences, School of Medicine, Department of Internal Medicine
  • Beza Leulseged Ayalew Addis Ababa University, College of Health Sciences, Department of Internal Medicine
  • Charles B. Sherman Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
  • Dawit Kebede Huluka Addis Ababa University, College of Health Sciences, School of Medicine, Department of Internal Medicine

Abstract

Tracheobronchomalacia (TBM) is an uncommon disease characterized by marked dilation of the trachea and mainstem bronchi, occurring as a result of atrophy or absence of elastic fibers and muscle tissues. Furthermore, atrophy of the connective tissue between the cartilage rings may result in the formation of diverticula, contributing to the development of recurrent respiratory infections. TBM may be congenital (Mounier-Kuhn Syndrome) or acquired. Patients can be asymptomatic or present with mild to severe disease with respiratory failure. We report the first case of TBM from East Africa in a 45-year-old woman with HIV disease. 

Author Biographies

Ermias Merkebu Amare, Addis Ababa University, College of Health Sciences, School of Medicine, Department of Internal Medicine
Internal Medicine Department, Pulmonary and Critical Care Medicine Division, Assistant Professor
Beza Leulseged Ayalew, Addis Ababa University, College of Health Sciences, Department of Internal Medicine
Department of Internal Medicine, Resident
Charles B. Sherman, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
Pulmonary and Critical care medicine division, Associate Professor
Dawit Kebede Huluka, Addis Ababa University, College of Health Sciences, School of Medicine, Department of Internal Medicine
Internal Medicine Department, Pulmonary and Critical Care Medicine Division, Assistant Professor

References

Celik F, Bilgin S, Yuksel C. Mounier-Kuhn syndrome: a rare cause of bronchial dilation. Tex Heart Inst J. 2011; 38(2): 194-6.

Bass EM. Tracheobronchomegaly: The Mounier-Kuhn Syndrome. South African Medical Journal (SAMJ). 1974; 48(40):1718-1720.

Mounier-Kuhn P. Dilatation de la trachee: constatations radiographiques et bronchoscopiques. Lyon Med. 1932; 150:106–9.

Marques A, Felix M, Barata F, Pires J, Helena E, Martinho do Bispo Coimbra S. Mounier-Kuhn syndrome: a rare aetiology of recurrent respiratory infections. Rev Port Pneumol. 2007; 13(5):721-7.

Sivanmani K. A case report of Mounier-Kuhn syndrome. J Assoc Chest Physicians. 2017; 5(1):39-41.

Bastos AL, Brito ILA. Mounier-Kuhn syndrome: radiological findings and clinical presentation. Radiol Bras. 2011: 44(3):198-200.

Haages JR, Boll D. Congenital Tracheobronchomegaly (Mounier-Kuhn syndrome): A case report of 10 cases and review of the literature. J Thorac Imaging 1991; 6:1-10.

Kheiralla OAM, Babikr WG, Globawe, MMA. Mounier-Kuhn syndrome: a case report and literature review. WJPMR. 2016: 2(3):13-16.

Lee JK. Computed Body Tomography with MRI Correlation. Vol 1. 2006. Philadelphia. Lippincott, Williams, and Wilkins.

Jain P, Dave M, Singh DP, Kumawat DC, Babel CS. Mounier-Kuhn Syndrome. Indian J Chest Dis Allied Sci. 2002; 44:195-198.

Published
2019-03-30