Immune protection of Hepatitis B vaccine among children living in Gondar town, Northwest Ethiopia, 2017


  • Getnet Ayalew
  • Abate Assefa
  • Anteneh Amsalu
  • Mekuanint Geta
  • Adane Mihret
  • Abraham Aseffa
  • Rawleigh Howe
  • Ebba Abate


Background: Hepatitis B virus infection is a worldwide health problem and highly endemic in developing countries including Ethiopia. Hepatitis B vaccine is included in the routine Expanded Program on Immunization since 2007 in Ethiopia.

Objective: The aim of this study was to assess the sero-protection level of hepatitis B vaccination among children who have received thevaccine.

Methods: A cross-sectional study was conducted among children attending Kindergarten and first cycle elementary school inGondar town.  A pre-tested structured questionnaire was used to collect the socio-demographic data. Blood sample was collected and serum separated for anti-HBs,anti-HBc and HBsAg. The data was analyzed using SPSS statistical software version 20. Binary logistic regression analysis was done. P-value less than 0.05 was considered as statistically significant.

Result:Out of 431 children screened, 27 were excluded from analysis because they were positive for anti-HBc(27/431, 6.3%) and/or for HBsAg (18/431 or 4.2%). Out of 404 children, 130 (32.2%) had anti-HBs titers >10 mIU/ml (seroprotected) while 274 (68.8%) had anti-HBs titers <10 mIU/ml (non-protected). 


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