Evaluation of topical 10% Potassium hydroxide solution versus 80% Trichloroacetic acid in the treatment of genital wart
Genital wart is one of the commonest sexually transmitted diseases caused by human papilloma virus. Many modalities of treatment are available with variable success rate, cost and side effect profiles but none is uniformly effective.
A prospective open -label non randomized comparative study done in patients with anogenital wart to compare the efficacy and side effect profile of 10% potassium hydroxide solution and 80% TCA in the treatment of genital wart. Over 15 months period patients with anogenital wart were assigned to either 10% KOH or 80% trichloroacetic acid alternately and the outcome was assessed.
Eighty two participants were completed the study. The mean duration of healing in weeks for KOH group is 4.1weeks (SD=2.7) while for TCA group it is 7.4weeks (SD=3.2). After adjusting for lesion size, lesion number and HIV status it is found that adjusted hazard ratio AHR for KOH is 1.98 (95% CI 1.16-3.38) which is significant with p value of 0.012. 7.5 % from KOH group and 14.3 % from TCA group has recurrences which is not statistically significant (p value = 0.68).
10% potassium hydroxide solution is effective in treatment of genital wart with shorter healing time when compared to 80% TCA. Thus it can be used as one of the treatment modalities in the treatment of genital wart.