Herpes Simplex Virus-1 Herpetic Meningoencephalitis in Adults: Three Cases in Casablanca, Morocco
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- Articles
- Submited: June 20, 2023
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Published: April 1, 2024
Abstract
Herpes simplex virus type 1 is the first cause of acute focal encephalitis with necrosis of the cerebral parenchyma in children and adults, with high morbidity. Herpes simplex virus type 2 is the main cause of herpetic meningitis in adults, with a good evolution. Herpetic meningoencephalitis is rarely caused by HSV-1. We report three observations of PCR-confirmed HSV-1 meningoencephalitis in cerebrospinal fluid in young immunocompetent adults aged 27, 53, and 58. They presented with a meningoencephalitis picture consisting of a meningeal syndrome and encephalic involvement. Lumbar puncture confirmed lymphocytic clear-fluid meningitis, with a median white blood cell count of 97, red blood cell count of 69, proteinorachia of 0.78, and glycorachia of 0.62.
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