ETHIOPIAN PATIENT WITH VISCERAL LEISHMANIASIS-ASSOCIATED HEMOPHAGOCYTICLYMPHOHISTIOCYTOSIS

Authors

  • Abilo Tadesse Weldetsadik
  • Zewdu Hurrisa
  • Ermias Diro

Abstract

A 29-year-old male patient was diagnosed to have visceral leishmaniasis at initial presentation, and later developed visceral leishmaniasis-associated hemophagocyticlymphohistiocytosis, as evidenced by persistent fever, worsening organomegaly and cytopenia, hyperferritinemia, hyperlipidemia, elevated transaminases, and hemophagocytosis in bone marrow aspirate. The case is presented and discussed with available literature review.

Key words: Visceral leishmaniasis, hemophagocyticlymphohistiocytosis.

 

References

Scott RB, Robb-Smith AHT. Histiocytic medullary reticulosis. Lancet. 1939;234:194-98.

Tothora Z, Berliner N. Hemophagocytic syndrome and critical illness: New insights into diagnosis and management. J Int Care Med. 2015;30(7):401-12 .

McClain KL, Eckstein O. Clinical features and diagnosis of hemophagocyticlymphohistiocytosis.Uptodate; 2016.Available from http://www.Uptodate.com.

George MR. Hemophagocyticlymphohistiocytosis: review of etiologies and management. J Blood Med.2014;5:69-86.

Unal S. Hemophagocyticlymphohistiocytosis: an update to diagnosis and management. ActaMedica.2014;3:29-34.

Rajagopala S, Singh N. Diagnosis and treating hemophagocyticlymphohistiocytosis in the tropics: systematic review from the Indian Subcontinent. Acta Medica Academica. 2012;41(2):161-74.

Cancado GGL, Freitas G, Faria FHF, Macedo AV, Nobre V. Hemophagocyticlymphohistiocytosis associated with visceral leishmaniasis in late adulthood. Am J Trop Med Hyg. 2013;88(3):575-77.

Mokhtari M, Kumar PV. Visceral leishmaniasis-associated hemophagocytosis: a single center experience. Arch Iran Med 2013;16(8):471-73.

HenterJ-I, Horne AC, Arico M, Egeler M, Filipovich AH, ImashukuS,et al.HLH-2004: Diagnostic and therapeutic guidelines for hemophagocyticlymphohistiocytosis. Pediatr Blood Cancer. 2007 Feb;48(2):124-31.

Kleynberg RL, Schiller GJ. Secondary hemophagocyticlymphohistiocytosis in adults: an update on diagnosis and therapy. ClinadvHematolOncol. 2012;10(11):726-32.

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Published

2018-02-19

How to Cite

Weldetsadik, A. T., Hurrisa, Z., & Diro, E. (2018). ETHIOPIAN PATIENT WITH VISCERAL LEISHMANIASIS-ASSOCIATED HEMOPHAGOCYTICLYMPHOHISTIOCYTOSIS. Ethiopian Medical Journal, 56(2). Retrieved from https://emjema.org/index.php/EMJ/article/view/611

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Section

Case Report