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The Effect of HIV Co-infection on Tuberculosis Treatment in Ethiopia: A Retrospective Cohort study.

Mengistu Yilma Dilnessie | Bio
Addis Ababa University
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  • Submited: March 3, 2018
  • Published: December 26, 2018

Abstract

Abstract Background: TB/HIV co-infection remains the major public health challenges worldwide. TB co-infection with HIV exacerbates the challenges in diagnosis and treatment of patients. The occurrence of these two diseases together can potentiate one another. This study was designed to determine the effect of HIV co-infection on tuberculosis treatment among tuberculosis patients.Methods: A retrospective cohort study was conducted on 1952 tuberculosis patients. The treatment outcomes of tuberculosis patients with HIV infection were compared with those who were HIV negative.Result: TB/HIV co-infected patients had significantly lower cure rate than HIV negative TB patients (10.3% vs 16.7%) with AOR=0.599, P<0.028 and 95%CI= 0.380-0.946. Treatment completion rate was significantly lower in TB/HIV co-infected patients than HIV negative TB patients (41.2% vs 47.2%) with AOR=0.584, P=0.001 and 95%CI=0.431-0.792. But TB/HIV co-infected patients had significantly higher death rate than HIV negative TB patients (10.2% vs 2.2%) with AOR=3.053, p<0.001 and 95%CI=1.736-5.378. Conclusion and recommendation: The effect of HIV co-infection was significantly higher on tuberculosis treatment. There was the significantly lower cure and completion rate while the death rate was higher among HIV positive tuberculosis patients. Strengthening TB and HIV collaboration activities is important to improve treatment outcome of TB patients. Keywords Retrospective, tuberculosis, Cure, completion, death
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How to Cite
Dilnessie, M. Y. (2018). The Effect of HIV Co-infection on Tuberculosis Treatment in Ethiopia: A Retrospective Cohort study. Ethiopian Medical Journal, 57(1). Retrieved from https://emjema.org/index.php/EMJ/article/view/948

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